OAD-TOF system
The OAD-TOF system is a Q-TOF LCMS that realizes OAD (Oxygen Attachment Dissociation), Shimadzu's proprietary fragmentation technology. It allows the analysis of the position of carbon-carbon double bonds in lipids and other organic compounds. Combined with the LCMS-9050, which boasts world-class high mass accuracy and fast polarity switching, it enables the creation of innovative applications.
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Product Description
The OAD-TOF system is a Q-TOF LCMS that realizes OAD (Oxygen Attachment Dissociation), Shimadzu's proprietary fragmentation technology. It allows the analysis of the position of carbon-carbon double bonds in lipids and other organic compounds. Combined with the LCMS-9050, which boasts world-class high mass accuracy and fast polarity switching, it enables the creation of innovative applications.
Technical specifications
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Innovative fragmentation technology
The OAD-TOF system is equipped with an OAD RADICAL SOURCE I, which enables Oxygen Attachment Dissociation (OAD) analysis, an innovative fragmentation that utilizes Shimadzu’s proprietary radical reaction. It can measure fragment ions that cannot be obtained by conventional collision-induced dissociation (CID), where ions are fragmented by collision with an inert gas such as argon or nitrogen. The irradiating oxygen radicals specifically oxidize/dissociate double bonds between carbons, which is useful for structure estimation of organic compounds such as lipids. The technique can be applied to monovalent ions and negative ions, which have been difficult to fragment using radical reactions by electrons and anions, and provides completely new structural information
Easy to switch between CID and OAD
CID is also possible with the OAD RADICAL SOURCE I installed. No special software is required, and LabSolutions™ LCMS control and analysis software for LCMS-9050 can easily switch between OAD and CID for analysis. Acquisition of a large amount of structural information by OAD and CID can lead to new discoveries in lipids and other organic compounds.
Reliable structure estimation with high mass accuracy
The high mass accuracy achieved with the LCMS-9050 remains unchanged even with OAD. High-quality MS/MS data within ±3 ppm enables reliable structure estimation of compounds, including determination of the position of carbon-carbon double bonds.
Creating endless possibilities
The OAD-TOF system can be used in combination with various options compatible with the LCMS-9050. The DPiMS™ QT, Kit for Direct Probe Ionization Mass Spectrometer, can be installed in place of the standard ESI unit for rapid analysis with simple pretreatment. It can also be connected to the Nexera™ UC supercritical fluid chromatography (SFC) system. This is especially useful for profiling lipids, where vast numbers of isomers exist.